George A. Sprecace M.D., J.D., F.A.C.P. and Allergy Associates of New London, P.C.
www.asthma-drsprecace.com


Occupational Asthma

Selected Causes of Occupational Asthma*
 
High Molecular Weight Compounds
Agents
Occupations
ANIMAL PRODUCTS:
Dander, Excreta Serium, Secretions
Animal Handlers, Laboratory Workers, Veterinarians
PLANTS:
Grain, Tea, Flour, Tobacco, Hops, Dust
Grain Handlers, Tea Workers, Bakers, natural Oil Manufacturing Workers, Tobacco and Food Processing Workers, Healthcare Workers
ENZYMES:
B. subtilis, Pancreatic Extracts, Papaln, Trypsin, Fungal Amylase
Bakers,
Detergent, Pharmaceutical, and Plastic Industry Workers
VEGATABLE:
Gum Acacla, 
Gum Tragacanth
Printers, Gum Manufacturing Workers
OTHER:
Crab, Prawn
Crab and Prawn Processors
Low Molecular Weight Compounds
Agents
Occupations
DIISOCYANATES:
Toluene Diisocyanate (TDI), Methylene Diphenyl Diisocyanate (MDI)
Polyurethane Industry Workers, Plastics Workers, Workers Using Varnish, Foundry Workers
ANHYDRIDES:
Phthallic Anhydrates, Trimeltic Anhydrates
Epoxy, Resin, and Plastics Workers
WOOD DUST:
Oak, Mahogany, California Redwood, Western Red Cedar
Carpenters, Sawmill Workers, Furniture Makers
METALS:
Platinum, Nickel, Chromium, Cobalt, Vanadium, Tungsten Carbide
Platinum and Nickel Refining Workers; Hard Metal Workers
SOLDERING FLUXES Solderers
DRUGS:
Penicillin, Methyldopa, Tetracyclines, Cephalosporins, Psyllium
Pharmaceutical and Healthcare Industry Workers
OTHER ORGANIC CHEMICALS:
Urea Formaldehyde, Dyes, Formalin, Azodicarbonamide, Hexachloroethylene Diamine, Dimethyl Ethanolamine, Polyvinyl Chloride Pyrolysates
Chemical, Plastic, and Rubber Industry Workers, Hospital Workers, Laboratory Workers, Foam Insulation Manufacturing Workers, Food Wrapping Workers, Spray Painters

*Mechanism believed to be igE-mediated for high molecular weight compounds and for some low molecular weight compounds. The immunologic mechanism for many low molecular weight substances remains ~ind~ fined. (Adapted from M. Chan-Yeung, S. Lam, Occupational Asthma. Am Rev Respir Dis, 1986; I33:686-703.


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